Introduction to Process Simulation using Aspen HYSYS is intended for participants who are using Aspen HYSYS for the first time and have little or no experience in computer simulation. It can be used as an introductory course in freshmen chemical engineering courses, or workshops where Aspen HYSYS is being taught. The course can also serve as a reference in more advanced chemical engineering courses when Aspen HYSYS is used as a tool for simulation and solving problems. It also can be used for self-directed study of Aspen HYSYS by students and practicing engineers. In addition, the course can be a supplement in courses where Aspen HYSYS is used, but the instructor does not have time to cover it extensively. This course has been interactively designed where every single chapter has it's own learning outcome with a simple activity as well as reflection. It is expected that participants will be able to articulate simulation skills obtained in this course to solve or plan the solution for complex chemical engineering process simulation problems.